Flupirtine: Preliminary Pharmacokinetics in the Donkey

Flupirtine: preliminary pharmacokinetics in the donkey

A Preliminary Assessment of HTST Processing on Donkey Milk

Due to increasing attention from consumers on non-bovine milk types, and to the increase in the number of small dairy donkey farms in Italy, farmers require more advanced and reliable processing devices, in order to guarantee a safe product of high quality. To this aim, a new small-scale High-Temperature Short-Time (HTST) pasteurizer (72 °C for 15 s), prototyped by the authors, was tested on do...

Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment.

The pharmacokinetics of flupirtine after a single oral dose of 100mg have been studied in patients with moderate renal impairment and in healthy elderly subjects aged 66-83 years. Mean elimination half-life of flupirtine was higher in elderly patients than in younger normal subjects, and this was associated with an increased maximum serum concentration and reduced clearance. The mean half-life ...

Preliminary Pharmacokinetics of Diclazuril and Toltrazuril in the Horse

This pilot study suggests that diclazuril and toltrazuril are absorbed after oral administration and have longer (40–55 h) plasma half-lives. These kinetic characteristics suggest readily maintained steady-state plasma concentrations. These are useful characteristics for therapeutic agents; however, therapeutic specifics for these agests in the horse remain to be determined. Authors’ address: M...

Peritesticular Fibromyxoma in a Donkey

Case Description- A seven-year-old male donkey was admitted with a history of left scrotal swelling with ulcerating wound since 2 years.Clinical Findings- The left scrotum was painful. There was ulcerating and hypergranulating wound discharging bloody discharge. The wall of the scrotum was found thick and infiltratedwith soft slimy non capsulated and lobulated fibrous tissue masses. The left te...